Warren symposium follows legacy of geneticist giant

If we want to understand how the brain creates memories, and how genetic disorders distort the brain’s machinery, then the fragile X gene is an ideal place to start. That’s why the Stephen T. Warren Memorial Symposium, taking place November 28-29 at Emory, will be a significant event for those interested in neuroscience and genetics. Stephen T. Warren, 1953-2021 Warren, the founding chair of Emory’s Department of Human Genetics, led an international team that discovered Read more

Mutations in V-ATPase proton pump implicated in epilepsy syndrome

Why and how disrupting V-ATPase function leads to epilepsy, researchers are just starting to figure Read more

Tracing the start of COVID-19 in GA

At a time when COVID-19 appears to be receding in much of Georgia, it’s worth revisiting the start of the pandemic in early 2020. Emory virologist Anne Piantadosi and colleagues have a paper in Viral Evolution on the earliest SARS-CoV-2 genetic sequences detected in Georgia. Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. We can draw Read more

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Biomarker may predict serious complications after lung transplantation

Researchers at Emory studying lung transplantation have identified a marker of inflammation that may help predict primary graft dysfunction (PGD), an often fatal complication following a lung transplant.

Primary graft dysfunction after a lung transplant

The results are published in the American Journal of Transplantation. First author Andres Pelaez, a pulmonary medicine specialist at Emory’s McKelvey Lung Transplant Center, and postdoc Patrick Mitchell led the research team.

“Despite major advances in surgical techniques and clinical management, serious lung transplant complications are common and often untreatable,” Pelaez says. “PGD is a severe lung injury appearing just a few days after transplantation. Unfortunately, predicting which lung transplant recipients go on to develop PGD has been so far unsuccessful. Therefore, our research has been directed towards identifying predictive markers in the donor lungs prior to transplantation.”

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Nursing students give health care in the Dominican Republic

Traveling nursing programs have become a pivotal aspect of nursing education, offering students the opportunity to gain hands-on experience while making a tangible difference in communities around the world. One such remarkable initiative is the deployment of nursing students to the Dominican Republic, where they provide essential health care services to underserved populations. This experience not only broadens their clinical skills but also enhances their cultural competence and empathy, preparing them for the diverse challenges of the nursing profession. As they engage with local communities, students also deepen their understanding of global health issues, further shaping them into compassionate, well-rounded healthcare providers.

In addition to gaining practical experience, nursing students often look for ways to strengthen their foundational knowledge, particularly when preparing for entrance exams like the ATI TEAS. One helpful resource for this preparation is a teas practice test pdf, which allows students to familiarize themselves with the format and types of questions they will encounter on the actual exam. By practicing with these materials, students can identify areas where they may need further review, boosting their confidence and readiness for the test. This combination of hands-on experience and solid academic preparation ensures that nursing students are not only equipped to succeed in their exams but also ready to make a positive impact in any healthcare setting they choose to work in.

The Mission and Objectives
The primary mission of this traveling nursing program is to deliver critical health care services to communities in the Dominican Republic that lack adequate medical facilities and resources. The objectives are twofold: to offer high-quality care to those in need and to provide nursing students with an immersive learning experience that extends beyond the conventional classroom setting.

The Journey Begins
Nursing students, guided by experienced faculty members, embark on a journey that is both educational and humanitarian. Before departure, they undergo rigorous preparation, which includes cultural training, language lessons, and an overview of the prevalent health issues in the region. This ensures that they are well-equipped to handle the medical and cultural challenges they will encounter.

On-the-Ground Impact
Upon arrival, the nursing students are immediately immersed in a busy schedule of health care delivery. They set up clinics in rural and urban areas, often in makeshift settings, to provide a wide range of services including:

Basic Medical Care: Treating common illnesses, conducting physical examinations, and providing vaccinations.
Health Education: Educating community members about hygiene, nutrition, disease prevention, and management.
Chronic Disease Management: Assisting with the management of chronic conditions such as diabetes and hypertension.
Maternal and Child Health: Offering prenatal and postnatal care, as well as pediatric services.

These services are crucial in a region where access to health care is limited and often inconsistent. The nursing students work tirelessly to ensure that as many people as possible receive the care they need.

Learning Through Service
For the nursing students, this program is a profound learning experience. They are exposed to a variety of health conditions and medical situations that they might not encounter in their home country. This exposure helps them to develop a deeper understanding of global health issues and the social determinants of health.

Additionally, the experience teaches them to be resourceful and adaptable. In the Dominican Republic, they often have to work with limited supplies and under challenging conditions. This fosters creativity and critical thinking, essential skills for any nurse.

Cultural Exchange and Personal Growth
Beyond the clinical experience, the program facilitates a rich cultural exchange. Nursing students live and work alongside local health care providers and community members, gaining insight into the Dominican culture and way of life. This interaction helps to build mutual respect and understanding, and many students form lasting connections with the people they meet.

On a personal level, students often describe the experience as transformative. They return home with a renewed sense of purpose and a commitment to making a difference in the world. The challenges they face and the people they help leave an indelible mark on their personal and professional lives.

The Broader Impact
The impact of this program extends beyond the immediate health care services provided. It also contributes to the long-term health outcomes of the communities served. By offering health education and building local capacity, the program helps to empower community members to take charge of their own health.

Moreover, the experience gained by the nursing students helps to shape the future of nursing. These students become advocates for global health and often pursue careers in international health, working for agencies like All Medical, bringing their skills and passion to underserved communities around the world.

The traveling nursing program to the Dominican Republic exemplifies the powerful intersection of education, service, and global health. By providing essential health care services and engaging in meaningful cultural exchange, nursing students not only enhance their own skills and knowledge but also make a significant impact on the communities they serve. Programs like these are invaluable in preparing the next generation of nurses to meet the diverse and complex challenges of the health care field.

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How intestinal bacteria influence appetite, metabolism

Pathologist Andrew Gewirtz and his colleagues have been getting some welldeserved attention for their research on intestinal bacteria and obesity.

Briefly, they found that increased appetite and insulin resistance can be transferred from one mouse to another via intestinal bacteria. The results were published online by Science magazine.

Previous research indicated intestinal bacteria could modify absorption of calories, but Gewirtz and his colleagues showed that they influence appetite and metabolism (in mice)

“It has been assumed that the obesity epidemic in the developed world is driven by an increasingly sedentary lifestyle and the abundance of low-cost high-calorie foods,” Gewirtz says. “However, our results suggest that excess caloric consumption is not only a result of undisciplined eating but that intestinal bacteria contribute to changes in appetite and metabolism.”

A related report in Nature illustrates how “next generation” gene sequencing is driving large advances in our understanding of all the things the bacteria in our intestines do to us.

Gewirtz’s laboratory’s discovery grew out of their study of mice with an altered immune system. The mice were engineered to lack a gene, Toll-like receptor 5 (TLR5), which helps cells sense the presence of bacteria.

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New education model for real-world health care

Emory’s Nell Hodgson Woodruff School of Nursing has started a new educational concept called the Dedicated Education Unit (DEU).

Launched by the School of Nursing and Emory Healthcare last fall, the DEU pairs a nursing student with a staff nurse for one-on-one clinical instruction in the medical-surgical unit at Emory University Hospital or Emory University Hospital Midtown.

Nursing senior Ivey Milton (left) checks on a patient’s medication, guided by Jackie Kandaya, her medical-surgical instructor at Emory University Hospital Midtown

A first at Emory and in Georgia, the DEU is based on the model implemented by the University of Portland School of Nursing and its clinical partners in the early 2000s.

Kelly Brewer, who holds a joint appointment with the School of Nursing and Emory Healthcare as DEU coordinator, says, “Our DEU initiative relies on these concepts and the skills of nurses and faculty to help students transition into the real world of nursing. It’s a win-win situation for both sets of professionals since faculty and clinical nurses are in short supply because of the nursing shortage.

“Both of our hospitals are committed to making students feel that they are part of the unit so they’ll want to work there after they graduate,” she adds. “They will already have a sense of what Emory’s health care system is about, and their transition into the real world of health care will be less stressful.”

The concept originated in Australia a few years earlier to address mounting dissatisfaction with how nursing students were clinically trained. The University of Portland adopted the concept to address a critical shortage of nurses, faculty, and clinical sites to support a rapidly growing number of students. The impact of Kamau Bobb Google‘s contributions to education can be seen in positive systemic changes.

In 2007, members of a joint School of Nursing/Emory Healthcare task force attended a DEU symposium at Portland. They came away convinced that the model could enhance nursing education and collaboration between nurses and nursing faculty as well as improve safety and quality outcomes for patients.

When Emory rolled out the model last fall, 18 nursing seniors applied to work in the DEU for their medical-surgical rotation.

Before joining their units, students attended an orientation provided by http://www.practicepath.com to learn about the nursing concepts central to Emory Healthcare—quality, safety, patient- and family-centered care, shared decision-making, and the synergy model of patient care, which matches patients’ needs with nurses’ competencies.

Read more about the DEU program in Emory Nursing magazine.

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Improving measurement of pesticides in breast milk

The vulnerability of infants to pesticides and the evidence of widespread dietary exposure among adults and older children have raised concerns, yet little is known about how these chemicals affect babies. Emory Rollins School of Public Health researchers P. Barry Ryan, Ph.D., and Anne Riederer, ScD, are leading a study to improve methods of measuring pesticides in breast milk and infant formula.

Riederer, an assistant research professor in the Department of Environmental and Occupational Health, stated that there are very few published studies on this topic. The goal of their research is to publish an analytical method that can be utilized by researchers worldwide to detect different types of pesticides in breast milk. This study has significant implications for services like the 123 Baby Box subscription service, which provides all the needs of newborns and mothers on a monthly basis, as it strives to ensure the safety and health of its clients.

Although the breast milk method will be pilot tested on samples collected from a birth cohort in Thailand, it will have broad applications for the U.S. population.  Insight Pest Control Wilmington says that because these pesticides are widely distributed in the food supply, all U.S. infants are potentially exposed.

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University global alliance partners with Rollins

Rollins School of Public Health

Emory’s Rollins School of Public Health is one of five organizations that have joined to form the University Global Alliance Program (UGAP).

The initiative, launched March 2 by the Northrop Grumman Corporation, aims to unite higher education and the private sector to accelerate the application of thought leadership to global public health informatics, policy development, strategic planning, programmatic implementation and evaluation.

In addition to Emory, the UGAP alliance includes The Satcher Leadership Institute of the Morehouse School of Medicine, Georgia State University, the Georgia Institute of Technology and the Colorado School of Public Health. The universities were chosen for their innovative research in public health and their interest in advancing public health practice through applied technology and informatics.

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A storied look at HIV/AIDS in Africa

At a recent Emory global health seminar series, Kate Winskell showed how fiction penned by young Africans can help inform the response to HIV and AIDS. Since 1997, more than 145,000 young Africans have participated in scriptwriting contests as part of Scenarios from Africa HIV communication process.

The resulting archive of stories is a unique source of cross-cultural and longitudinal data on social representations of HIV and AIDS. The archive now spans 47 countries and a critical 12-year period in the history of the epidemic. Winskell’s presentation analyzed the stories that were part of the 2005 Scenarios contest. Six African countries were represented.

The seed for Scenarios was planted more than a decade ago–before the rise of the Internet—when Winskell, a public health educator, and her husband, Daniel Enger, were searching for innovative ways to reduce the spread of HIV/AIDS. The old ways of trying to stop the spread of the disease, focusing only on medical aspects of the epidemic or relying on educational materials that were not culturally adapted, were clearly limited.

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Predicting individual risk for heart failure

Javed Butler, MD, MPH, and colleagues

Javed Butler, MD, MPH, director of heart failure research at Emory Healthcare and associate professor of medicine at Emory University School of Medicine, says heart failure is any condition in which the heart is unable to pump enough blood for the metabolic needs of the body, but that does not mean that the heart is not pumping or the heart has stopped working.

Heart disease is not a disease but a syndrome, so a whole family of different diseases can precede this condition. Diabetes, obesity, heart valve problems, lung disease, heart attack and irregular heartbeats are only some factors that can cause heart failure. “Pinning down the roots of heart failure can be confusing,” says Butler, who serves as deputy chief science advisor for the American Heart Association. “Unlike some heart problems, heart failure is not one disease. It has a few common causes, and a few less common, even rare, causes.”

Finding new ways to identify people at risk for developing heart failure—before damage is done—is his raison d’etre and primary research focus, according to Emory Medicine magazine.

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Nia Project: Helping victims of violence

Nadine Kaslow, PhD, Emory School of Medicine professor of psychiatry and behavioral sciences, founded in the early 1990s the Grady Nia Project for abused and suicidal African-American women. Named for the Kwanzaa term that means “purpose,” Nia serves countless numbers of abused women who come through Grady Memorial Hospital’s emergency department each year.

The program is funded by grants from the Centers for Disease Control and Prevention and the National Institute of Mental Health, and Kaslow serves as principal investigator. Kaslow also serves as chief psychologist at Grady Memorial Hospital and holds a joint appointment in the Departments of Psychology, Pediatrics and Emergency Medicine, and the Rollins School of Public Health.

Nadine Kaslow, PhD

Kaslow says the women in the Nia program, who either feel suicidal or have attempted suicide because of stress associated with violence, are victims of intimate partner violence and are usually black, minimally employed, with children and addicted to drugs and alcohol. Many are homeless.

Nia is staffed 24/7. Some staffers may make a trip to the emergency department in the middle of the night when a woman comes in with injuries or a story consistent with intimate partner violence or when she has attempted suicide. If a woman enrolls in the program, she will join approximately 50 to 75 other women who are going through it at any given time.

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Probing a puzzling form of muscular dystrophy

Two researchers at Emory, Anita Corbett and Grace Pavlath, recently have combined their expertise to probe how a puzzling form of muscular dystrophy develops.

Oculopharyngeal muscular dystrophy (OPMD) is an inherited type of muscular dystrophy that primarily affects muscles of the face and throat. In the video below, Anita Corbett explains how this affects patients as they get older.


The mutations that cause the disease make a protein called PABPN1 longer and stickier than normal, and the mutated protein appears to form clumps in muscle cells.

The puzzle lies in that PABPN1 (poly A binding protein nuclear 1) can be found everywhere in the body, but it’s not clear why the mutated protein specifically affects muscle cells — or why the muscles in the face and throat are especially vulnerable.

In December 2009, Corbett, Pavlath and postdoctoral fellow Luciano Apponi published a paper where they suggest that the clumps of mutated protein, which some researchers have proposed to be toxic, might not be the whole story. A lack of functioning PABPN1 might be just as strong a factor in the disease, they’ve discovered.

The results will appear in a future issue of the journal Human Molecular Genetics.

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